Spectral karyotyping

Spectral karyotyping (SKY)

Published: 13/10/2010 Received: 02/02/2010 ecancer 2010, 4:181 DOI: 10.3332/ecancer.2010.181 Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the origin...

Erratum: Spectral Karyotyping (SKY)

Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Spectral karyotyping of Werner syndrome fibroblast cultures.

Fibroblast cultures from two Werner syndrome patients were analyzed by spectral karyotyping. There were multiple, pseudodiploid clones in both cultures, mostly marked by random balanced reciprocal translocations. One of the cultures contained a clone with three-way exchanges involving chromosomes 2, 3, and 16. Duplication-deficiencies were exceptional, as were completely normal metaphases. The ...

Spectral Karyotyping and Comparative Genomic Hybridization Data

Spectral Karyotyping (SKY) (1–7) and Comparative Genomic Hybidization (CGH) (8– 11) are complementary fluorescent molecular cytogenetic techniques that have revolutionized the detection of chromosomal abnormalities. SKY permits the simultaneous visualization of all human or mouse chromosomes in a different color, facilitating the detection of chromosomal translocations and rearrangements (Figur...

Computer assisted spectral karyotyping and its promising clinical application